Pharmaceutical intermediates Diethyl(phenylacetyl)malonate - Names and Identifiers
Pharmaceutical intermediates Diethyl(phenylacetyl)malonate - Physico-chemical Properties
| Molecular Formula | C15H18O5
|
| Molar Mass | 278.3 |
| Density | 1.148±0.06 g/cm3(Predicted) |
| Melting Point | 120 °C(Press: 0.01 Torr) |
| pKa | 8.76±0.59(Predicted) |
| Use | Uses Organic synthesis intermediates. |
Pharmaceutical intermediates Diethyl(phenylacetyl)malonate - Introduction
Also known as Diethyl malonate, with the chemical formula C16H20O5, is an organic compound. Its properties are as follows:
Physical properties: Diethyl(phenylacetyl)malonate is a colorless to light yellow oily liquid with a low melting point and boiling point.
chemical properties: it can be hydrolyzed under acidic conditions to generate phenylacetyl malonic acid diacetic acid (diethylphenylacetoacetic acid) and ethanol.
Usage: Diethyl(phenylacetyl)malonate is mainly used as an intermediate in organic synthesis. It can be used for the preparation of medicaments, pharmaceutically active compounds, in particular acetylcholinesterase inhibitors of the epinephrine mimetic class.
preparation method: a common method for preparing Diethyl(phenylacetyl)malonate is to use Malonic acid (Malonic acid) and Phenylacetyl chloride (phenylacetyl chloride) as raw materials, the reaction is carried out by esterification in the presence of an acid catalyst.
Safety information: Diethyl(phenylacetyl)malonate is generally less toxic and irritant when used and stored properly. However, it is still a chemical and should be subject to safe practices. Use protective gloves and safety glasses to avoid contact with skin, eyes and inhalation of vapors. If accidental splashing or inhalation occurs, seek medical attention immediately.
Last Update：2024-04-09 20:45:29